IN VITRO ANTIOXIDANT AND ANTICANCER ACTIVITY OF THE FRUIT EXTRACT OF RIVINA HUMILIS L. (RED PIGEON BERRY)

The purpose of this study was to evaluate the cytotoxic and antioxidant properties a hydromethanolic extract Rivina humilis L fruits (HMERH) on human cancer cell lines various in vitro models. HMERH concentrations ranging from 5 400mg/ml were utilized several assay methods such as hydroxyl radicals, DPPH, superoxide radical scavenging activity, metal chelating, nitric oxide test, ABTS, reducing power assay. All assays employed ascorbic acid standard. Its short-term cytotoxicity EAC DLA cells determined using trypan blue dye exclusion method, well lactate dehydrogenase (LDH) leakage MEF-L929, DU-145, PC-3 MTT total potential also phosphomolybdenum test. demonstrated considerable against all examined. findings free activities concentration-dependent antiradical activity caused by reduction NO, OH, SO radicals non-radical form. reveal that antioxidants agents have potent effects lines. Hence, fruit has be natural anticancer drug source, which could valuable development new therapies.